School of Medicine

Wayne State University School of Medicine

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James G. Granneman, Ph.D.
Professor
University Health Center - 4H
4201 St. Antoine
Detroit, MI 48201
Biography

Education:

  • B.A., Psychology, Southern Illinois University 1976
  • Ph.D., Biopsychology, University of Massachusetts 1981
  • Post Doc, Endo/Metabolism, University of Rochester School of Medicine 1981-1982
  • Post Doc, Neurobiology, University of Pittsburgh 1982-1985

Positions and Honors:

  • 1981-1982 - I nstructor and Fellow in Medicine (Endocrinology and Metabolism), University of Rochester School of Medicine
  • 1982-1985 - Research Associate, Department of Biological Sciences, University of Pittsburgh
  • 1985-1991 - Chief, Laboratory of Biochemical Pharmacology
  • 1986-1991 - Center for Cell Biology, Sinai Research Institute, Assistant Professor of Psychiatry, Wayne State University School of Medicine
  • 1991-1996 - Associate Professor of Psychiatry (Tenured)
  • 1996-date - Wayne State University School of Medicine Professor of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine
  • 1998-2001 - Research Fellow, Cell Biology, Parke-Davis/Pfizer Global Research and Development, Ann Arbor
  • 2001-date - Director, Center for Integrative and Metabolic Research Professor of Pathology, Wayne State University School of Medicine

Awards & Honors:

  • 1972-1976 - Illinois State Scholar
  • 1979-1980 - NIMH Predoctoral Trainee, University of Massachusetts
  • 1981-1982 - Postdoctoral Fellow in Diabetes, Endocrine and Metabolic
  • 1981-1982 - Research, (NIADDK) Univ. of Rochester School of Medicine
  • 1983-1985 - National Research Service Award (NINCDS)
  • 1998 - Department Research Excellence Award
  • 2001-Present - Editorial Board, Am. J. Physiology (Endocrinology and Metabolism)
  • 2002 - Editorial Board, J. Experimental Diabetes Research
  • 2002-2006 - Grant Review Panel, American Diabetes Association, NIH Cellular Aspects of Diabetes and Obesity (Ad Hoc)
Research

Ongoing Research:

  • RA29 (J. Granneman, PI)
    American Diabetes Association 7/01/06 – 6/30/09
    “Analysis of lipolytic trafficking” The aims of this grant are to 1) characterize the temporal and spatial interactions of Plin-interacting proteins in live model cells adipocytes, focusing on HSL and Abhd5, and 2) to test the hypothesis that Abhd5 modulates the onset and termination of hormone stimulated lipolysis.
  • Ro1 DK62292 (J. Granneman, PI) 5
    /31/03 – 9/30/11 NIH NIDDK
    “Analysis of cellular plasticity in white adipose tissue” The project examines the plasticity of cellular phenotypes in white fat during catabolic stimulation by beta 3 receptor agonists.
  • Ro1 DK066164-01 (Dhurandhar NV, PI; Granneman, Investigator)
    9/1/2003 – 8/31/2007 NIH / NIDDK
    “Mechanism of Promotion of Adipogenesis by Adenovirus-36” The project examines the mechanisms by which Ad-36 promotes adipogenesis.

Completed:

  • R21 DK 66505 Granneman, JG (PI)
    9/01/03 – 1/31/07 NIH/NIDDK
    “Analysis of therapeutic adipose tissue remodeling” This project seeks to develop a transgenic model for inducible genetic manipulation. This model will then be used for lineage tracing in two drug models of adipose tissue remodeling.
  • MLSC 27, Granneman, JG (PD)
    9/01/02 – 8/31/06 Michigan Economic Development Commission
    “Michigan Diabetes Research Consortium” This project was a consortium of labs from Univ. Michigan, Michigan State Univ. and Wayne State Univ. The goal of the consortium was to develop and test new models of obesity/diabetes.
  • RO1 DK46339 Granneman, JG
    (PI) 12/01/93 - 6/30/03 NIH/NIDDK
    “Analysis of beta1 and beta3 adrenoreceptors” This project examined the differential pharmacological and signaling properties of beta1 and beta3 receptors in adipocytes.
  • Ro1 MH60854-01 (M. Bannon, PI, Granneman, Co-PI)
    12/01/99- 11/30/04 NIMH
    “Analysis of striatal-specific RGS9” This project evaluated the subcellular targeting, regulation and signaling properties of RGS9-L, a RGS subtype expressed in dopamine target cells. Responsibilities of Dr.Granneman (Co-PI) included yeast two-hybrid analysis
Peer-Reviewed Publications
  • Granneman, J.G., Lahners, K.N. and A. Chaudhry: Molecular cloning and expression of the rat beta3adrenergic receptor. Mol. Pharmacol. 40: 895-899, 1991.
  • Granneman, J.G.: Effects of agonist exposure on the coupling of ß1- and ß3-adrenergic receptors to adenylyl cyclase in isolated adipocytes. J. Pharmacol. Exper. Ther. 261: 638-642, 1992.
  • Granneman, J.G., K.N. Lahners and D.D. Rao. Rodent and human ß3-adrenergic receptor genes contain an intron within the protein-coding block. Mol. Pharmacol. 42:964-970, 1992.
  • Granneman, J.G., K.N. Lahners and A. Chaudhry. Characterization of the human ß3 adrenergic receptor gene. Mol. Pharmacol. 44:264-270, 1993.
  • Granneman, J.G. and K.N. Lahners. Analysis of human and rodent ß3-adrenergic receptor messenger ribonucleic acids. Endocrinology 135: 1025-1031, 1994.
  • Granneman, J.G. Expression of adenylyl cyclase subtypes in brown adipose tissue: Neural regulation of type III. Endocrinology 136: 2007-2012, 1995.
  • Chaudhry, A., L.M. Muffler, R. Yao and J.G. Granneman. Perinatal expression of adenylyl cyclase subtypes in rat brown adipose tissue. Am. J. Physiol. (Reg. Integ.) 270: R755-760, 1996.
  • Granneman, J.G., Y. Zhai and K.N. Lahners. Selective upregulation of a1a-adrenergic receptor mRNA and protein in brown adipose tissue by neural and ß3-adrenergic stimulation. Mol. Pharmacol., 51: 644-650, 1997.
  • Chaudhry, A. and J.G. Granneman. Effect of hypothyroidism on adenylyl cyclase activity and subtype gene expression in brown adipose tissue. Am. J. Physiol. (Reg. Integ.) 273:R762-R767, 1997.
  • Granneman, J.G., R.P. Skoff and X. Yang. A member of the peroxisome proliferator activated receptor family of transcription factors is differentially expressed in oligodendrocytes. J. Neurosci. Res., 51: 563-573, 1998.
  • Granneman, J.G., K.N. Lahners and Y. Zhai. Agonist interactions with chimeric and mutant b1- and b3-adrenergic receptors: Involvement of the seventh transmembrane region in conferring subtype specificity. Mol. Pharmacol.,53: 856-862, 1998.
  • Granneman, J.G., Y. Zhai, Z. Zhu, M.J. Bannon, S. A. Burchett, C.J. Schmidt, R. Andrade and J. Cooper. Molecular characterization of human and rat RGS9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS9 gene. Mol. Pharmacol., 54:687-694, 199.
  • Burchett, S.A., M.J. Bannon and J.G. Granneman. RGS expression in rat striatum: modulation by dopamine receptors and effects of repeated amphetamine administration. J. Neurochem., 72: 1529-1533, 1999.
  • Chaudhry, A. and J.G. Granneman. Differential regulation of functional responses by b-adrenergic receptor subtypes in brown adipocytes. Am. J. Physiol. (Reg. Integ.), 277: R147-153, 1999.
  • Ikezu, Y., S. Yashuhara, J.G. Granneman, F.B. Kraemer, T. Okamoto, R.G. Tompkins and J.A. Martyn. A unique mechanism of desensitization to lipolysis mediated by b3-adrenoceptor in rats with thermal injury. Am. J. Physiol. (Endo.), 277: E316-E324, 1999.
  • Konkar, AA., Y. Zhai and J.G. Granneman. b1-adrenergic receptors mediate b3-adrenergic-independent effects of CGP 12177 in brown adipose tissue. Mol. Pharmacol. 57:252-258, 2000.
  • Konkar, AA., Z. Zhu and J.G. Granneman. Aryloxypropanolamine and catecholamine ligand interactions with the beta(1)-adrenergic receptor: evidence for interaction with distinct conformations of beta(1)-adrenergic receptors. J. Pharmacol. Exp. Ther. 294:923-32, 2000.
  • Granneman, J.G. Beta 3 adrenergic receptors as a therapeutic target for obesity. Handbook of Experimental Pharmacology: obesity: Pathology and Therapy (D. Lockwood and T. Heffner, eds), Springer-Verlag, 2000.
  • Sacchetti, P., T.R. Mitchell, J.G. Granneman and M.J. Bannon. Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism. J. Neurochem., 76: 1565-1577, 2001.
  • Saluja, I., J.G. Granneman and R.P. Skoff. PPARd agonists promote oligodendrocyte differentiation in vitro. Glia, 33: 199-208, 2001.
  • Granneman, J.G. The b4-adrenergic receptor is a novel state of the b1-adrenergic receptor: Implications for receptor classification and drug discovery. Am. J. Physiol. (Endocrinology and Metabolism), 280: E199-202, 2001.
  • Chaudhry, A. Z. Zhang and J.G. Granneman. Characterization of RIIb and D-AKAP-1 in differentiated adipocytes. Am. J. Physiol. (Cell), 282: C205-212, 2002.
  • Bannon M.J., B. Pruetz, A.B. Manning-Bog, C.J. Whitty, S.K. Michelhaugh, P. Sacchetti, J.G. Granneman, D.C. Mash and C.J. Schmidt. Decreased expression of the transcription factor Nurr1 in dopamine neurons of cocaine abusers. Proc. Natl. Acad. Sci. U.S.A. 99:6382-6385, 2002.
  • Granneman, JG, M Burnazi, Z Zhu and LS Schwamb. White adipose tissue contributes to UCP1-independent thermogenesis. Am J Physiol Endo Metab;285(6):E1230-6, 2003.
  • Leff, T and JG Granneman. The adipocyte: Diabetes, obesity and the fat cell. Encyclopedia of Molecular Biology and Medicine, Wiley-VCH Verlag, Weinheim, Germany, 2004.
  • Granneman, JG, P Li, Y Lu and J Tilak. Seeing the trees in the forest: selective electroporation of adipocytes within adipose tissue. Am J Physiol Endocrinol Metab 287(3):E574-82, 2004.
  • Granneman, JG P Li, Z Zhu and Y Lu. Metabolic and cellular plasticity in white adipose tissue I: Effects of b3-adrenergic receptor activation. Am J Physiol Endocrinol Metab 289: E608-616, 2005.
  • Li, P, Z Zhu, Y Lu and JG Granneman. Metabolic and cellular plasticity in white adipose tissue II: Role of peroxisome proliferator activated receptor alpha. Am J Physiol Endocrinol Metab 289: E617-E262, 2005.
  • Moore, HP. RB Silver, EP Mottillo, DA Bernlohr and JG Granneman PerilipinTargets a Novel Pool of Lipid Droplets for Lipolytic attack by hormone-sensitive lipase. J Biol Chem. 280(52):43109-20, 2005.
  • Granneman, JG. Delivery of DNA into adipocytes within adipose tissue. Electroporation protocols: Experimental and Clinical Medicine, S. Li (ed) Human Press, 2006.
  • Granneman, JG HP Moore, RL Granneman, AS Greenberg, AS Obin and Z Zhu. Analysis of lipolytic protein trafficking and interactions in adipocytes. J Biol Chem. 2006 Dec 21; [Epub ahead of print] PMID: 17189257

 

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